Description

Sitagliptin + Metformin is a combination drug used in the treatment of type 2 diabetes mellitus. Type 2 diabetes occurs when the body is unable to produce enough insulin or when the body’s insulin is unable to work as well as it should. It can also occur if the body produces more glucagon. Insulin is a substance that helps to lower the level of sugar in your blood, especially after meals.

Sitagliptin and Metformin contain two active ingredients:

• Sitagliptin: Helps control blood sugar levels by causing the pancreas to produce more insulin and less glucagon.
• Metformin: Helps the body utilise insulin more effectively.

Uses of Sitagliptin and Metformin Tablets

Sitagliptin + Metformin is mainly employed for the management of Type 2 Diabetes Mellitus.

• Management of Diabetes: It is mainly used in combination with diet and exercise to control blood sugar levels in type 2 diabetes patients.
• Improvement of Glycemic Control: It enhances glycemic control as a whole through the increase of insulin sensitivity and the reduction of glucose production in the liver.
• Weight Management: It can be a support in the area of weight management for certain patients with diabetes by making them less hungry or changing their fat metabolism.
• Prevention of Diabetes Complications: Long-term use of the drug helps to avoid the occurrence of neuropathy (damage to the nerves), nephropathy (damage to the kidneys), and retinopathy (damage to the eyes), which are all complications associated with diabetes. 

Side Effects of Sitagliptin + Metformin

While not everyone gets side effects, common ones may include:

• Hypoglycemia (low blood sugar) – characterised by dizziness, sweating, hunger pangs, dry mouth, etc.
• Nausea & Vomiting
• Diarrhoea & Stomach pain
• Headache
• Upper respiratory symptoms (Runny nose, Sore throat)
• Gas & Indigestion

Drug Warnings

• Allergies: Do not use if allergic to Sitagliptin or Metformin.
• Lactic Acidosis: A rare but serious condition where too much lactic acid accumulates in the blood. Risk factors include kidney disease, dehydration, and excessive alcohol intake.
• Pancreatitis: Inform your doctor if you have ever had inflammation of the pancreas.
• Vitamin B12: Prolonged use may lower Vitamin B12 levels.
• Hypoglycemia: When used with insulin, blood sugar may drop significantly.
• Medical Procedures: Stop taking this medicine for a short time before X-ray procedures involving dye injections.

Precautions To Be Taken

Alcohol: Avoid consumption of alcohol while on treatment.

Pregnancy:  Recommended only when benefits outweigh risks.

Breastfeeding:  Use only if the benefits outweigh the risks.

Driving: Do not drive if you experience drowsiness or lack of focus.

Liver/Kidney:  Essential if you have a history of liver or kidney disease.

Children:  Advisable to seek medical advice before use.

Note: The above content is only for educational purposes and does not guarantee anything. Therefore, must inform your doctor before taking Sitagliptin and Metformin Tablets. 

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Frequently Asked Questions (FAQs)

What is Sitagliptin + Metformin used for?

It is prescribed for the treatment of Type 2 Diabetes Mellitus to help regulate blood sugar levels, often combined with diet and exercise changes.

How does this medication work?

Metformin improves how the body uses sugar, while Sitagliptin stimulates the pancreas to release more insulin, preventing high blood sugar after meals.

Does Sitagliptin + Metformin cause low blood sugar?

Generally, no, but hypoglycemia can occur if taken with other diabetes medicines, during strenuous exercise, or if meals are skipped.

Is it safe to drink alcohol while taking this tablet?

No, alcohol consumption is unsafe as it increases the risk of lactic acidosis, a rare but life-threatening condition affecting the blood.

What are the most common side effects?

Side effects may include nausea, vomiting, diarrhoea, headache, and upper respiratory symptoms like a sore throat or runny nose.